Best Seller
The Nightly Performance Capsule for executives, founders and dealmakers who drink for work.
Free shipping over $50 · Tax calculated at checkout
How OftenFourteen clinically-dosed actives across three capsules. Every milligram on the label. No proprietary blends, no pixie dust.
Capsule 1 — Liver Defense (in every tier)
Capsule 2 — Brain Protection (SYN-2 and SYN-3)
Capsule 3 — Heavy Night Damage Control (SYN-3 only)
Take 4 capsules with your last drink of the night — or with 12oz of water before bed. That's it.
For especially heavy nights or back-to-back drinking days, take a second 4-capsule dose 6 hours after the first. Not for daily use — SYN is built for the nights that count.
Pair the protocol with the included travel case so a 4-pack sits in your jacket pocket before dinner.
Free shipping on US orders $50+. Ships in 24 hours. Most orders arrive in 2–4 business days.
30-Night Money-Back Guarantee. Try the full first bottle. If your mornings don't measurably improve, email us within 30 days and we'll refund the order. Keep the bottle, the case, and the protocol card.
All shipments arrive in discreet, unbranded packaging with a neutral billing descriptor on your card.
SYN is MD-formulated, manufactured in a GMP-certified, FDA-registered facility, and third-party tested every batch for purity and potency.
If you're on prescription medication or have a liver condition, talk to your physician first. Not for use under the age of 21.
Customers Documenting What Their First Month on Protocol Actually Feels Like.
Four Reasons SYN Replaces Hangover Pills, Drugstore Vitamins and the Morning-After Scramble.
Wake up clear-headed even after a two-bottle dinner. Cognition, not just hydration.
Clinically-dosed ingredients for everything alcohol disrupts.
Hepatologist + neuroscientist + sports MD. Third-party tested. GMP certified.
Unbranded shipping. Leather travel case. Fits a jacket pocket.
What Three Drinking Nights a Week Actually Look Like — Before and After You Add SYN to Your Protocol.
Without SYN
With SYN
Twenty Clinically-Dosed Ingredients. Every Milligram on the Label.
Glutathione Precursor
Alcohol Metabolism Catalyst
Hepatocyte Repair
Acetylcholine Precursor
Hepatoprotective Herb
Adaptogen / Cortisol Brake
Anti-inflammatory Stack
Gut Lining Protection
"Two-bottle dinners with a 7am standup used to mean ibuprofen and lies. SYN means I show up the same person I was at noon. The most honest edge I've added to my week in five years."
Marcus D. · Managing Director, M&A · NYC
What 1,800+ Verified Subscribers Reported After Their First Thirty Nights on the SYN Protocol.
*Aggregated from verified subscriber surveys, Q1 2026. Individual results vary by drinking pattern, sleep and baseline.
Most-Asked Questions From Executives, Founders and Dealmakers — Direct Answers, No Fluff.
SYN is built for executives, founders, partners and dealmakers who drink for work and need to perform the next morning.
Hangover pills sell you a fix. SYN is protection. Twenty clinically-dosed ingredients that protect your liver, cognition, sleep, stress and hydration — taken before the damage compounds.
Take 4 capsules with your last drink of the night (or with water before bed). That's it.
Subscribe & Save delivers your protocol every 30 days at 20% off, free shipping, with the welcome kit on month one. Skip, pause, or cancel any month from your account in two clicks.
30-Night Money-Back Guarantee. Try the full first bottle. If your mornings don't measurably improve, we refund the order. Keep the bottle, the case, the card.
SYN is MD-formulated, manufactured in a GMP-certified, FDA-registered facility, and third-party tested every batch.
There's a reason SYN has so many 5-star reviews...
Two-bottle dinners with a 7am standup used to mean ibuprofen and lies. SYN means I show up the same person I was at noon. The most honest edge I've added to my week in five years. Three weeks in, I haven't missed a morning workout.
Product reviewed: SYN — NightlyI spent years negotiating drink count with water glasses and skipped courses. SYN gave me a real protocol I actually respect. Three months in, I won't host a dinner without it. The next-day cognition is the part I notice most — depositions feel like depositions, not survival.
Product reviewed: SYN — NightlyFounder dinner Wednesday, red-eye Thursday, board meeting Friday at 8am. The old version of me would be cooked. SYN-R the next morning is my tell-nobody edge — half my exec team is on the protocol now and we never talk about it.
Product reviewed: SYN — NightlyWanted something more serious than Flyby and less theatrical than the gym-bro biohacks. SYN reads like a real formulation — every milligram on the label, no proprietary blends — and the morning-after results back it up. Worth every dollar of the subscription.
Product reviewed: SYN — NightlyThe cortisol-spike thing is real. I used to wake at 4 a.m. with my heart racing after a heavy night. Two weeks on SYN — the spike is gone. I sleep through. Honestly the most measurable change I've felt from a supplement, and I'm a skeptical doctor.
Product reviewed: SYN — NightlyThree back-to-back conference dinners used to wreck me by Thursday. With SYN at the table and SYN-R the next morning, day three still feels like day one. Carry the case in my jacket pocket — discreet, easy.
Product reviewed: SYN — Nightly
