4.9 · 2,400+ reviews

Drink For Work. Wake Up Sharp.

The Nightly Performance Capsule for executives, founders and dealmakers. Twenty clinically-dosed ingredients, taken with your last drink — so you wake up clear-headed, sharp, and ready for the 7 a.m.

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30-Night Money-Back Guarantee · Skip or cancel anytime
Third-Party Tested GMP Certified MD-Formulated
Live Tonight · Lead TomorrowSYN forest-green carton with gold and silver blister packs — Prime + Restore, 10 capsules
How It Works

Stack Your Protection.

Each Capsule Builds On The Last. Take More When The Night Demands More.

SYN carton — the foundation protocol
01 30 Min Before Drinks · 2 Caps

The Foundation

Your metabolic shield. Activates the liver's acetaldehyde clearance pathway before alcohol hits your bloodstream.

  • Accelerates alcohol metabolism by ~38%
  • Protects liver cells against oxidative stress
  • Reduces next-day inflammation markers
NAC 160mg Milk Thistle 120mg 6-Herb Hepato Blend 202mg Electrolytes + B6
SYN Shop
SYN open — blister revealed, what is inside
02 Second Round · +1 Cap

Cognitive Clarity

The booster layer. 480mg NAC + Alpha-GPC stack glutathione and preserve acetylcholine — so your mind stays sharp mid-dinner and razor-edged at 7 a.m.

  • Doubles glutathione recycling capacity
  • Preserves acetylcholine signalling
  • Eliminates next-morning brain-fog
NAC 480mg total Alpha-GPC 160mg Choline Precursor BBB-Crossing
SYN+ Shop
Single SYN capsule — the active formula
03 Before Bed · 2 Caps

Peak Performance

The recovery protocol. Adaptogens and anti-inflammatories repair sleep architecture and reset HPA-axis cortisol — you wake up at 100%, not 60%.

  • Restores deep-sleep architecture
  • Resets HPA-axis cortisol rhythm
  • Quiets systemic inflammation
DHM 240mg Rhodiola 100mg Ginger 80mg Turmeric + Piperine 60mg
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Real Mornings

See The Morning After.

Customers Documenting What Their First Month on Protocol Actually Feels Like.

"7 a.m. felt normal."Marcus · M&A · NYC
"My 4 a.m. is gone."Elena · GC · AmLaw 50
"3 dinners a week, no debt."James · CEO · SaaS
"It's the sleep, actually."Ravi · PE · Stamford
What You Get

Built For The Working Pro.

Four Reasons SYN Replaces Hangover Pills, Drugstore Vitamins and the Morning-After Scramble.

Sharper Mornings

Wake up clear-headed even after a two-bottle dinner. Cognition, not just hydration.

Real Protection

Clinically-dosed ingredients for everything alcohol disrupts — your liver, your cognition, your sleep, your stress, your hydration.

MD-Formulated

Built with a hepatologist, neuroscientist and sports MD. Third-party tested. GMP certified.

Discreet & Travel-Ready

Unbranded shipping. Leather travel case. Fits a jacket pocket. Built for the way you actually work.

Ingredients

Inside Every SYN Bottle.

Twenty Clinically-Dosed Ingredients. Every Milligram on the Label.

N-Acetyl Cysteine

N-Acetyl Cysteine

Glutathione Precursor

Dihydromyricetin

Dihydromyricetin

Alcohol Metabolism Catalyst

Milk Thistle

Milk Thistle

Hepatocyte Repair

Alpha-GPC

Alpha-GPC

Acetylcholine Precursor

Andrographis

Andrographis

Hepatoprotective Herb

Rhodiola Rosea

Rhodiola Rosea

Adaptogen / Cortisol Brake

Turmeric + Piperine

Turmeric + Piperine

Anti-inflammatory Stack

Ginger Root

Ginger Root

Gut Lining Protection

The Science

Why Protection Beats Recovery.

Short Explainers From Our Medical Advisors on Alcohol, the Liver, and the Morning After.

The Liver PathwayDr. Patel · Hepatology
Why Sleep BreaksDr. Chen · Neuroscience
The 4 a.m. Cortisol SpikeDr. Rivera · Sports MD
Why DHM WorksLab Notes · 2 min
Step 01

The dinner begins.

9:30 p.m. The wine pours. Your last drink is also your first SYN — four capsules before the espresso. The liver primes. The cortisol clock resets.

Read The Science
Step 02

The body protects.

DHM and NAC clear acetaldehyde overnight. Alpha-GPC protects acetylcholine so cognition rebuilds. Rhodiola brakes the 4 a.m. cortisol spike before it lands.

Read The Science
Step 03

The morning arrives.

7 a.m. — the alarm hits the same. So do you. Cognition is sharp, the liver is clean, the sleep is logged. The version of you that walked in the room last night is the one walking out today.

Read The Science
Step 04

The week compounds.

Three drinking nights in a row used to mean Friday felt like Wednesday felt like Monday. With SYN, the recovery debt never gets a chance to accumulate. You stay you.

Read The Science

Which Protocol Is Right For You?

Pick by Use Case — Every Product Clicks Through to Its Own PDP.

Best For
Liver support
Cognition
Sleep architecture
Cortisol modulation
Take when
01SYN Nightly carton

SYN Nightly

Best Seller
Every drinking night
With last drink
02SYN+ — two cartons

SYN+ Plus

Heavy Nights
2-bottle dinners
With last drink
03SYN-R — open carton with capsules

SYN-R Recovery

Morning
Morning rebuild
On waking
4.9 · 1,847 verified reviews

Meet SYN Nightly.

The base protocol. Four capsules with your last drink, every night you drink. Twenty clinically-dosed ingredients, built for the way working professionals actually entertain. Wake up clear-headed, sharp, ready for the 7 a.m. — every time.

  • 20 clinically-dosed ingredients — every milligram on the label
  • Built for your liver, cognition, sleep, stress and hydration
  • 30-night money-back guarantee · Free shipping · Skip anytime
Questions

You've Got Questions? We've Got The Answers.

Most-Asked Questions From Executives, Founders and Dealmakers — Direct Answers, No Fluff.

Who is SYN actually for?

SYN is built for executives, founders, partners and dealmakers who drink for work and need to perform the next morning. Client dinners, board reveals, conferences — situations where opting out of the drink isn't an option, but showing up foggy at 7 a.m. isn't either.

How is this different from a hangover pill?

Hangover pills sell you a fix. SYN is protection. 20 clinically-dosed ingredients that protect your liver, cognition, sleep, stress and hydration — taken before the damage compounds.

When and how do I take it?

Take 4 capsules with your last drink of the night (or with water before bed). That's it. Pair with the included travel case so it's there when you need it.

Is it safe?

SYN is MD-formulated, manufactured in a GMP-certified, FDA-registered facility, and third-party tested every batch. Talk to your physician if you're on prescription medication or have a liver condition.

When will I notice it?

The first morning. Most customers report a clearer head, no anxiety spike, and easier focus on the very first use. The adaptogenic ingredients compound after about 14 days.

How does Subscribe & Save work?

Subscribe & Save delivers your protocol every 30 days at 20% off, free shipping, with the welcome kit on month one. Skip, pause, or cancel any month from your account in two clicks.

What if it doesn't work for me?

30-night money-back guarantee. Try the full first bottle. If your mornings don't measurably improve, email us and we refund the order. Keep the bottle, the case, the card.

Let's Hear It From Them.

4.9 · 2,401 reviews
See all reviews
Marcus D. Verified Buyer 04/22/26

"7 a.m. self matches my 11 p.m. self."

Two-bottle dinners with a 7am standup used to mean ibuprofen and lies. SYN means I show up the same person I was at noon. The most honest edge I've added to my week in five years. Read more

SYN Nightly
Elena H. Verified Buyer 04/21/26

"A real protocol I respect."

I spent years negotiating drink count with water glasses and skipped courses. SYN gave me a real protocol I actually respect. Three months in, I won't host a dinner without it. Read more

SYN+ Plus
James K. Verified Buyer 04/20/26

"My tell-nobody edge."

Founder dinner Wednesday, red-eye Thursday, board meeting Friday at 8am. The old version of me would be cooked. SYN-R is my tell-nobody edge. Read more

SYN-R Recovery
Ravi P. Verified Buyer 04/19/26

"Reads like a real formulation."

Wanted something more serious than Flyby and less theatrical than the gym-bro biohacks. SYN reads like a real formulation — and the morning-after results back it up. Read more

SYN Nightly
Priya S. Verified Buyer 04/18/26

"I sleep through the 4 a.m."

The cortisol-spike thing is real. I used to wake at 4 a.m. with my heart racing after a heavy night. Two weeks on SYN — the spike is gone. I sleep through. Read more

SYN+ Plus
Daniel L. Verified Buyer 04/17/26

"Conference weeks finally work."

Three back-to-back conference dinners used to wreck me. With SYN-R the next morning, day three still feels like day one. The most useful supplement I've ever bought. Read more

SYN-R Recovery